反应条件
1: 89 percent / LiAlH4 / tetrahydrofuran / 2 h / -10 - 15 °C
2: 86 percent / HBr / 1 h / 100 - 110 °C
3: 1.) LiNH2 / 1.) liq. NH3, from -50 deg C to -40 deg C, 0.5 h, 2.) THF, liq. NH3, a) -33 deg C, 1 h, b) RT, 4 h
4: NaI / dimethylsulfoxide / 1.5 h / 100 - 125 °C
5: 10percent aq. NaOH / 5 h / 90 - 100 °C
View Scheme
参考文献
Ivanov; Groza; Mal'chenko; Myagkova; Shewe
Russian Journal of Bioorganic Chemistry, 1997 , vol. 23, # 6 p. 481 - 487
