反应条件
1: NaH / toluene; dimethylformamide / 16 h / Ambient temperature 2: NBS, H2O / acetonitrile / 0.25 h / 15 °C 3: conc. HBr, HOAc / 1.25 h / 90 °C 4: 28 percent / toluene / Heating 5: 1.) NH3 (liq.), Na / 2.) MeOH, 45 deg C, 15 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1074 - 1090