4-羟甲基-4'-甲基-2,2'-联吡啶合成路线 (共 9 条)
反应条件
1: With acetic anhydride T=65°C; 17 h; 2: With sodium hydroxide in ethanol; water 0.5 h; Reflux;
参考文献
Kodama, Koichi; Kobayashi, Akinori; Hirose, Takuji
Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5514 - 5517
反应条件
1: With selenium(IV) oxide in 1,4-dioxane 24 h; Reflux; 2: With sodium tetrahydroborate in methanol T=20°C; 1 h;
参考文献
Li, Minna; Liang, Qichao; Zheng, Meiqing; Fang, Chenjie; Peng, Shiqi; Zhao, Ming
Dalton Transactions, 2013 , vol. 42, # 37 p. 13509 - 13515
反应条件
sodium tetrahydroborate in ethanol 1.5 h; Ambient temperature;
参考文献
Furue, Masaoki; Yoshidzumi, Toshiyuki; Kinoshita, Shuichi; Kushida, Takashi; Nozakura, Shun-ichi; Kamachi, Mikiharu
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 5 p. 1632 - 1640
反应条件
1: Raney-Ni 2: SeO2 / dioxane / 24 h / Heating 3: NaBH4 / ethanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 52 p. 12849 - 12858
反应条件
sodium hydroxide; acetic anhydride 1.) 60-65 deg C, 24 h, 2.) aq. EtOH, reflux, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 54, # 7 p. 1731 - 1735
反应条件
manganese(IV) oxide in dichloromethane Ambient temperatureovernight;
参考文献
Ciana, Leopoldo Della; Hamachi, Itaru; Meyer, Thomas J.
Journal of Organic Chemistry, 1989 , vol. 54, # 7 p. 1731 - 1735
反应条件
sulfuric acid; hydrogen bromide Heating;
参考文献
Berg, Katja E.; Tran, Anh; Raymond, Mary Katherine; Abrahamsson, Malin; Wolny, Juliusz; Redon, Sophie; Andersson, Mikael; Sun, Licheng; Styring, Stenbjoern; Hammarstroem, Leif; Toftlund, Hans; Akermark, Bjoern
European Journal of Inorganic Chemistry, 2001 , # 4 p. 1019 - 1029
反应条件
triethylamine in chloroform
T=20°C;
参考文献
Fushimi, Toshiki; Oda, Akimichi; Ohkita, Hideo; Ito, Shinzaburo
Journal of Physical Chemistry B, 2004 , vol. 108, # 49 p. 18897 - 18902
反应条件
1: SO2Br / CH2Cl2
2: Ambient temperature
View Scheme
参考文献
Furue, Masaoki; Yoshidzumi, Toshiyuki; Kinoshita, Shuichi; Kushida, Takashi; Nozakura, Shun-ichi; Kamachi, Mikiharu
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 5 p. 1632 - 1640