3-溴-1-甲基-2-吡啶酮合成路线 （共 6 条）
反应条件
bromine; potassium bromide in water pH dependence; Rate constantMechanismProduct distribution;
参考文献
Bradlow; Vanderwerf
Journal of Organic Chemistry, 1951 , vol. 16, p. 73,79
反应条件
potassium carbonate in dimethyl sulfoxide
T=20°C;
参考文献
Becknell, Nadine C.; Lyons, Jacquelyn A.; Aimone, Lisa D.; Gruner, John A.; Mathiasen, Joanne R.; Raddatz, Rita; Hudkins, Robert L.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7076 - 7080
反应条件
sodium methylate in methanol
T=50 - 60°C; 3 h;
参考文献
Tee, Oswald S.; Paventi, Martino
Journal of the American Chemical Society, 1982 , vol. 104, # 15 p. 4142 - 4146
参考文献
Elan Pharmaceuticals, Inc.
Patent: US6465513 B1, 2002 ;
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=-10°C; 4 h; temperature 10 deg C; Product distribution;
参考文献
Shusherina, N.P.; Likhomanova, T.I.; Nikolaeva, S.N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1284 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1662 - 1664
反应条件
und Behandeln des Reaktionsprodukts in Wasser mit Kalium-hexacyanoferrat(III) und wss.Kalilauge;
参考文献
Bradlow; Vanderwerf
Journal of Organic Chemistry, 1951 , vol. 16, p. 73,79
