1-甲基-1H-1,2,4-噻唑-5-羧酸合成路线 （共 1 条）
反应条件
1: 1-methyl-1H-1,2,4-triazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Inert atmosphere;
2: carbon dioxide in tetrahydrofuran; hexane
T=-78 - 20°C;
3: With water in tetrahydrofuran; hexane
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/147188 A1, 2009 ;
Location in patent: Page/Page column 99 ;
WO 2009/147188 A1
