4-羟基-2,2,5,5-四甲基-己烷-3-酮合成路线 （共 40 条）
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=-25°C; 10 h;
参考文献
Shineer, Cristofer S.; Berks, Andrew H.; Fisher, Allison, M.
Journal of the American Chemical Society, 1988 , vol. 110, # 3 p. 957 - 958
反应条件
sodium hydroxide in anhydrous N,N-diethylformamide T=110°C; 2 h;
参考文献
AIR PRODUCTS AND CHEMICALS, INC.
Patent: US2012/35351 A1, 2012 ;
Location in patent: Page/Page column 26 ;
反应条件
tert.-butyl lithium in tetrahydrofuran T=-78°C;
参考文献
Journal of the American Chemical Society, , vol. 112, # 1 p. 455 - 457
反应条件
in tetrahydrofuran; dimethyl-ether T=-135°C;
参考文献
Seyferth, Dietmar; Weinstein, Robert M.; Hui, Richard C.; Wang, Wei-Liang; Archer, Colin M.
Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5620 - 5629
反应条件
methyl-magnesium chloride in tetrahydrofuran; perdeuterocyclohexane T=60°C; 2 h; sealed tube;
参考文献
Knorr; Boehrer; Schubert
Chemistry - A European Journal, 2012 , vol. 18, # 24 p. 7506 - 7515
反应条件
tributylphosphine; copper (I) cyanide in tetrahydrofuran 1.) -78 deg C; 2.) -78 deg C, 1.5 h; RT, 2 h;
参考文献
Kabalka, George W.; Li, Nan-Sheng; Yu, Su
Tetrahedron Letters, 1997 , vol. 38, # 13 p. 2203 - 2206
反应条件
samarium diiodide in tetrahydrofuran 0.333333 h; Ambient temperature;
参考文献
Girard, P.; Couffignal, R.; Kagan, H. B.
Tetrahedron Letters, 1981 , vol. 22, # 40 p. 3959 - 3960
反应条件
tributylphosphine; copper (I) cyanide in tetrahydrofuran 1.) -78 deg C; 2.) -78 deg C, 1.5 h; RT, 2 h;
参考文献
Kabalka, George W.; Li, Nan-Sheng; Yu, Su
Tetrahedron Letters, 1997 , vol. 38, # 13 p. 2203 - 2206
参考文献
Bulletin de la Societe Chimique de France, , vol. <3>35, p. 644,646
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 140, p. 1699
Organic Syntheses, , vol. 13, p. 26
反应条件
sodium in diethyl ether 1.) reflux, 0.5 h, 2.) r.t., overnight;
参考文献
Liebigs Annales, , # 1 p. 193 - 202
