N-二苯亚甲基-甘氨酸叔丁酯合成路线 （共 23 条）
反应条件
Multistep reaction. Title compound not separated from byproducts.;
参考文献
European Journal of Organic Chemistry, , # 13 p. 2905 - 2913
反应条件
1: 92 percent / aq. KOH / O-allyl-N-(9-anthracenyl)methylcinchonidium bromide / toluene / 14 h 2: 96 percent / aq. citric acid / tetrahydrofuran 3: 68 percent / NaBH4; LiCl / tetrahydrofuran; ethanol / 0 °C 4: 83 percent / triphenylphosphane; bromine; imidazole / CH2Cl2 / 3 h / 0 °C View Scheme
参考文献
Siebum, Arjan H. G.; Tsang, Robert K. F.; Van Der Steen, Rob; Raap, Jan; Lugtenburg, Johan
European Journal of Organic Chemistry, 2004 , # 21 p. 4391 - 4396
反应条件
Multistep reaction. Title compound not separated from byproducts.;
参考文献
Siebum, Arjan H. G.; Woo, Wei Sein; Raap, Jan; Lugtenburg, Johan
European Journal of Organic Chemistry, 2004 , # 13 p. 2905 - 2913
反应条件
1: With phosphazene base P1-t-bu-tris(tetramethylene); Cinchona alkaloid derived chiral ammonium salt in chloroform; toluene T=-50°C; 2 h; 2: With hydrogenchloride in tetrahydrofuran T=0°C; 1 h;
参考文献
Mettath, Sashikumar; Srikanth; Dangerfield, Benjamin S.; Castle, Steven L.
Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6489 - 6492
反应条件
1: With n-butyllithium; (-)-sparteine in toluene T=-78°C; 3 h; 2: With trifluoroacetic acid in dichloromethane; water T=25°C; 3: With hydrogenchloride in water 1 h; Further stages. Title compound not separated from byproducts.;
参考文献
Organic Letters, , vol. 4, # 11 p. 1883 - 1886
反应条件
1: aq. KOH; C2-symmetric chiral quaternary ammonium salt / toluene / 0 °C 2: aq. citric acid / tetrahydrofuran / 10 h / 20 °C 3: H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 112, # 1 p. 95 - 99
反应条件
1: With sodium hydroxide; (R)-NOBIN in dichloromethane T=20°C; 1 h; 2: With hydrogenchloride in methanol; water Heating;
参考文献
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Larionov, Oleg V.; Harutyunyan, Syuzanna R.; Vyskocil, Stepan; North, Michael; Kagan, Henri B.
Angewandte Chemie - International Edition, 2001 , vol. 40, # 10 p. 1948 - 1951
反应条件
potassium hydroxide; hydrogen cation; 1-[(anthracene-9-yl)methyl]dihydrocinchonidinium chloride 1.) PhMe, H2O, 18 h, RT; 2.) H2O; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Lygo; Crosby; Lowdon; Wainwright
Tetrahedron, 2001 , vol. 57, # 12 p. 2391 - 2402
反应条件
potassium hydroxide; hydrogen cation; N-anthracenyl methyl cinchonidium chloride 1.) PhMe, H2O, 18 h, RT; 2.) H2O; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Lygo; Crosby; Lowdon; Peterson; Wainwright
Tetrahedron, 2001 , vol. 57, # 12 p. 2403 - 2409
反应条件
potassium hydroxide; hydrogen cation; N-anthracenyl methyl cinchonidium chloride 1.) PhMe, H2O, 4 h, RT; 2.) H2O; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Lygo; Crosby; Lowdon; Peterson; Wainwright
Tetrahedron, 2001 , vol. 57, # 12 p. 2403 - 2409
