N-二苯亚甲基-甘氨酸叔丁酯合成路线 （共 23 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 12 h; Heating;
参考文献
Danner, Paulami; Bauer, Matthias; Phukan, Prodeep; Maier, Martin E.
European Journal of Organic Chemistry, 2005 , # 2 p. 317 - 325
反应条件
T=20°C; 3 h; neat (no solvent);
参考文献
Nun, Pierrick; Perez, Violaine; Calmes, Monique; Martinez, Jean; Lamaty, Frederic
Chemistry - A European Journal, 2012 , vol. 18, # 12 p. 3773 - 3779
反应条件
toluene-4-sulfonic acid in toluene Reflux;
参考文献
US2011/21527 A1, ;
Page/Page column 23 ;
反应条件
1: spiropentyl bromide With tert.-butyl lithium in diethyl ether; pentane T=-78°C; Metallation; 1 h; 2: in tetrahydrofuran T=-110 - -40°C; complex formation; 20 h; 3: tert-butyl-acetyloxydiphenylmethyleneaminoacetate in tetrahydrofuran T=-10°C; Substitution; 6.5 h;
参考文献
De Meijere, Armin; Ernst, Katrin; Zuck, Bernd; Brandl, Melanie; Kozhushkov, Sergei I.; Tamm, Markus; Yufit, Dmitrii S.; Howard, Judith A. K.; Labahn, Thomas
European Journal of Organic Chemistry, 1999 , # 11 p. 3105 - 3115
反应条件
in dichloromethane T=20°C; 24 h;
参考文献
Siebum, Arjan H. G.; Woo, Wei Sein; Lugtenburg, Johan
European Journal of Organic Chemistry, 2003 , # 23 p. 4664 - 4678
反应条件
1: 92 percent / hydrogen / Pd/C / ethanol 2: 98 percent / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 4664 - 4678
反应条件
potassium carbonate T=130°C;
参考文献
Ramachandran, P. Veeraraghavan; Madhi, Sateesh; O'Donnell, Martin J.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 1 p. 78 - 83
反应条件
1: 87 percent / NH3 / diethyl ether / -40 °C 2: 98 percent / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 4664 - 4678
反应条件
1: 43 percent / (S,S)-[(4-MeBn)2N(1+)(Me)CH2]2-dioxolane-2,2-di-Pr*2BF4(1-); Cs2CO3 / chlorobenzene / 10 h / -30 °C 2: 93 percent / Pd/C; H2 / tetrahydrofuran / 20 h View Scheme
参考文献
Ohshima, Takashi; Gnanadesikan, Vijay; Shibuguchi, Tomoyuki; Fukuta, Yuhei; Nemoto, Tetsuhiro; Shibasaki, Masakatsu
Journal of the American Chemical Society, 2003 , vol. 125, # 37 p. 11206 - 11207
反应条件
1: With n-butyllithium; (-)-sparteine in toluene T=-78°C; 3 h; 2: With trifluoroacetic acid in dichloromethane; water T=25°C; 3: With hydrogenchloride in water 1 h; Further stages. Title compound not separated from byproducts.;
参考文献
Organic Letters, , vol. 4, # 11 p. 1883 - 1886
