1,7,8,9-四氢-5-甲氧基-9-氧代-吡喃并(2,3-g)吲哚-2-羧酸合成路线 (共 11 条)
反应条件
potassium hydroxide in water
参考文献
Societe de Recherches Industrielles
Patent: US4436915 A1, 1984 ;
反应条件
potassium hydroxide; water
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
1: 1) NaOH / 1) H2O, reflux, 15 min; 2) H2O, reflux, 50 min
2: 1) H3PO4, P2O5 / 1) benzene, 4 h, reflux; 2) benzene 12 h, reflux
3: 82 percent / 3 percent p-toluenesulfonic acid / toluene / 7 h / Heating
4: 1) n-BuLi / 1) ether, -70 deg C, 6 h; 2) ether, 12 h, -70 deg C
5: Na / methanol / 168 h / 0 °C
6: xylene / 3 h / Heating
7: conc. HCl, H2O / ethanol / 18 h
8: 93 percent / KOH, H2O
View Scheme
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
1: Br2
2: 1) NaOH / 1) H2O, reflux, 15 min; 2) H2O, reflux, 50 min
3: 1) H3PO4, P2O5 / 1) benzene, 4 h, reflux; 2) benzene 12 h, reflux
4: 82 percent / 3 percent p-toluenesulfonic acid / toluene / 7 h / Heating
5: 1) n-BuLi / 1) ether, -70 deg C, 6 h; 2) ether, 12 h, -70 deg C
6: Na / methanol / 168 h / 0 °C
7: xylene / 3 h / Heating
8: conc. HCl, H2O / ethanol / 18 h
9: 93 percent / KOH, H2O
View Scheme
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
1: 1) H3PO4, P2O5 / 1) benzene, 4 h, reflux; 2) benzene 12 h, reflux
2: 82 percent / 3 percent p-toluenesulfonic acid / toluene / 7 h / Heating
3: 1) n-BuLi / 1) ether, -70 deg C, 6 h; 2) ether, 12 h, -70 deg C
4: Na / methanol / 168 h / 0 °C
5: xylene / 3 h / Heating
6: conc. HCl, H2O / ethanol / 18 h
7: 93 percent / KOH, H2O
View Scheme
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
1: 1) n-BuLi / 1) ether, -70 deg C, 6 h; 2) ether, 12 h, -70 deg C
2: Na / methanol / 168 h / 0 °C
3: xylene / 3 h / Heating
4: conc. HCl, H2O / ethanol / 18 h
5: 93 percent / KOH, H2O
View Scheme
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
1: Na / methanol / 168 h / 0 °C
2: xylene / 3 h / Heating
3: conc. HCl, H2O / ethanol / 18 h
4: 93 percent / KOH, H2O
View Scheme
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
1: conc. HCl, H2O / ethanol / 18 h
2: 93 percent / KOH, H2O
View Scheme
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
1: 82 percent / 3 percent p-toluenesulfonic acid / toluene / 7 h / Heating
2: 1) n-BuLi / 1) ether, -70 deg C, 6 h; 2) ether, 12 h, -70 deg C
3: Na / methanol / 168 h / 0 °C
4: xylene / 3 h / Heating
5: conc. HCl, H2O / ethanol / 18 h
6: 93 percent / KOH, H2O
View Scheme
参考文献
Kim, Phieo Ta; Cocolios, Panayotis; Guilard, Roger
Canadian Journal of Chemistry, 1982 , vol. 60, p. 2099 - 2103
反应条件
copper (II) chromite in quinoline
参考文献
Societe de Recherches Industrielles
Patent: US4436915 A1, 1984 ;