5,6-二氨基-1,3-二丙基嘧啶-2,4(1H,3H)-二酮合成路线 （共 32 条）
反应条件
sodium dithionite in water
参考文献
Daly, J.W.; Padgett, W.; Shamim, M.T.; Butts-Lamb, P.; Waters, J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 487 - 492
反应条件
1: NaNO2; aq. HCl 2: NH2NH2 / Pd/C View Scheme
参考文献
Farmaco, , vol. 60, # 8 p. 643 - 651
反应条件
1: Ac2O 2: NaNO2; aq. HCl 3: NH2NH2 / Pd/C View Scheme
参考文献
Farmaco, , vol. 60, # 8 p. 643 - 651
反应条件
1: 1 h; Reflux; 2: With sodium hydroxide in ethanol; water 1 h; Reflux;
参考文献
Baraldi, Pier Giovanni; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Romagnoli, Romeo; Saponaro, Giulia; Baraldi, Stefania; Botta, Maurizio; Bernardini, Cesare; Tafi, Andrea; Tuccinardi, Tiziano; Martinelli, Adriano; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 24 p. 10281 - 10294
反应条件
T=100°C; 3 h; Inert atmosphere;
参考文献
Liu, Gang; Reddy, P.S. Murali; Barber, Jack R.; Ng, Shi Chung; Zhou, Yuefen
Synthetic Communications, 2010 , vol. 40, # 10 p. 1418 - 1436
反应条件
1: Py 2: aq. NaOH View Scheme
参考文献
Searle and Co.
Patent: US2602795 , 1950 ;
反应条件
1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(N,N-dimethylamino)pyridine, imidazole / dimethylformamide / 3 h / Ambient temperature 2: 4 N aq. NaOH / methanol / 2 h / 60 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Shimada, Junichi; Koike, Nobuaki; Nonaka, Hiromi; Shiozaki, Shizuo; Yanagawa, Koji; Kanda, Tomoyuki; Kobayashi, Hiroyuki; Ichimura, Michio; Nakamura, Joji; Kase, Hiroshi; Suzuki, Fumio
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2349 - 2352
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5756735 A1, 1998 ;
US 5756735 A
反应条件
1: 1) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 2) 1N NaOH / 1) dioxane, H2O, 2) dioxane, H2O, reflux 2: K2CO3 / dimethylformamide / 50 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
