5’-O-(4,4’-二甲氧基三苯甲基)尿苷合成路线 （共 15 条）
反应条件
pyridine T=20°C; 1 h;
参考文献
Journal of the American Chemical Society, , vol. 132, # 21 p. 7231 - 7233
反应条件
Ce(OTf)4; diethylazodicarboxylate in acetonitrile T=20°C; 2 h; Molecular sieve;
参考文献
Canadian Journal of Chemistry, , vol. 88, # 6 p. 563 - 568
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 2 h; Reactivity;
参考文献
EP2006293 A2, ;
Page/Page column 17 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.0166667 h; Reactivity;
参考文献
EP2479182 A1, ;
Page/Page column 21-22 ;
反应条件
1: N-iodo-succinimide / trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 1.17 h / -78.2 - 0 °C / Molecular sieve 2: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 0.83 h / 20 °C 3: pyridine / 15 h / 20 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.02 h / 20 °C View Scheme
反应条件
1: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 0.83 h / 20 °C 2: pyridine / 15 h / 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.02 h / 20 °C View Scheme
反应条件
1: pyridine / 15 h / 20 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.02 h / 20 °C View Scheme
反应条件
K 10 clay in methanol; water T=75°C; 0.5 h;
参考文献
Asakura, Jun-Ichi; Robins, Morris J.; Asaka, Yukihiro; Kirn, Tong Hei
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9026 - 9027
反应条件
1: pyridine / CH2Cl2 / 1) ice-bath, 15 min; 2) 20 deg C, 3 h 2: aq. NaOH / ethanol / 1 h / 60 °C 3: 82 percent / aq. AcOH / 0.5 h / 20 °C View Scheme
参考文献
Webb; Mitsuya; Broder
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1475 - 1479
反应条件
tin(ll) chloride in 1,4-dioxane; ethylene glycol dimethyl ether 0.333333 h; Ambient temperature;
参考文献
Helvetica Chimica Acta, , vol. 79, # 8 p. 2114 - 2136
