2-甲氧基-4-甲基苯甲酸甲酯合成路线 （共 34 条）
反应条件
1: With potassium carbonate in acetone 14 h; Heating / reflux; 2: With ammonia in methanol; water T=20°C; 0.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO KG
Patent: WO2004/108673 A2, 2004 ;
Location in patent: Page 45-46 ;
反应条件
1: 4-methylsalicylic acid methyl ester With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=20°C; 18 h;
参考文献
Itoh, Yukihiro; Kitaguchi, Risa; Ishikawa, Minoru; Naito, Mikihiko; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 22 p. 6768 - 6778
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/108677 A1, 2004 ;
Location in patent: Page 198-199 ;
WO 2004/108677 A1
反应条件
potassium carbonate in acetone Heating;
参考文献
Tyman, John H. P.; Visani, Naina
Journal of Chemical Research, Miniprint, 1997 , # 1 p. 228 - 240
反应条件
1: 1.) tBuLi, N,N,N',N",N"-pentamethyldiethylenetriamine / 1.) hexane, 25 deg C, 16 h. 2: diethyl ether View Scheme
参考文献
Tetrahedron, , vol. 54, # 12 p. 2763 - 2770
反应条件
1: 86 percent / 1,8-diazabicyclo<5.4.0>undecene / acetonitrile 2: 90 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 1 p. 228 - 240
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane T=25°C; without TMEDA, other metallating agent, solvent and temperature; Product distribution;
参考文献
Tetrahedron, , vol. 39, # 12 p. 2031 - 2042
反应条件
in toluene Heating; Yield given;
参考文献
Tetrahedron Letters, , vol. 29, # 13 p. 1595 - 1596
反应条件
in diethyl ether Yield given;
参考文献
Tetrahedron, , vol. 54, # 12 p. 2763 - 2770
参考文献
Bulletin de la Societe Chimique de France, , p. 2255 - 2261
