1: in methanol 4 h; Reflux; 2: With hydrogenchloride in methanol; diethyl ether

in methanol 4 h; Heating;

1: 3-(4-hydroxyphenyl)-propionic acid methyl ester With potassium carbonate in acetone T=20°C; 5 h; Inert atmosphereSchlenk techniqueSealed tube; 2: epichlorohydrin in acetone 20 h; RefluxSchlenk techniqueInert atmosphereSealed tube;

sodium hydroxide in water; acetone; toluene

potassium carbonate in butanone 8 h; Heating;

1: KOH / dimethylsulfoxide / 40 °C 2: K2CO3 / dimethylformamide / 15 h / 70 °C View Scheme

1.1: palladium (II) trifluoroacetate; 2,2,2-trimethylacetic acid; potassium carbonate / 120 °C / |Schlenk technique; |Inert atmosphere; |Sealed tube 2.1: sulfuric acid / 10 h / |Reflux; |Inert atmosphere; |Schlenk technique; |Sealed tube 3.1: potassium carbonate / acetone / 5 h / 20 °C / |Inert atmosphere; |Schlenk technique; |Sealed tube 3.2: 20 h / |Reflux; |Schlenk technique; |Inert atmosphere; |Sealed tube View Scheme

potassium carbonate in N,N-dimethyl-formamide T=70°C; 15 h;

1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C 2: potassium carbonate / acetonitrile / 6 h / Reflux View Scheme

1: dichloromethane / 6 h / 20 °C 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C 3: potassium carbonate / acetonitrile / 6 h / Reflux View Scheme