4-(3-羟基丙基)苯甲醛合成路线 （共 10 条）
反应条件
air; CAN-charcoal system in 1,4-dioxane
T=100°C; 16 h;
参考文献
Hatanaka, Yasuo; Imamoto, Tsuneo; Yokoyama, Masataka
Tetrahedron Letters, 1983 , vol. 24, # 23 p. 2399 - 2400
反应条件
1: With lithium aluminium tetrahydride in diethyl ether
T=0°C; 1 h; Heating / reflux;
2: With sodium hydroxide in water
T=20°C; 0.166667 h;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1609798 A1, 2005 ;
Location in patent: Page/Page column 64 ;
反应条件
imidazolium dichromate in N,N-dimethyl-formamide
4 h; Ambient temperature;
参考文献
Kim, Sunggak; Lhim, Dong Chul
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, p. 3297 - 3298
反应条件
[bis(acetoxy)iodo]benzene; sodium hydrogencarbonate in chloroform
T=60°C; Polonovski type reaction; 2 h; chemoselective reaction;
参考文献
Desjardins, Samuel; Jacquemot, Guillaume; Canesi, Sylvain
Synlett, 2012 , vol. 23, # 10 art. no. ST-2012-S0193-L, p. 1497 - 1500
反应条件
hydrogenchloride; water in methanol
T=60°C; 2 h;
参考文献
Lazzarato, Loretta; Donnola, Monica; Rolando, Barbara; Chegaev, Konstantin; Marini, Elisabetta; Cena, Clara; Di Stilo, Antonella; Fruttero, Roberta; Biondi, Stefano; Ongini, Ennio; Gasco, Alberto
Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5058 - 5068
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
1 h; Heating;
参考文献
Lee, Eun; Lee, Chulbom; Tae, Jin Sung; Whang, Ho Sung; Li, Kap Sok
Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2343 - 2346
反应条件
1: H2; DIPEA / palladium monocarbide / ethanol
2: LiAlH4 / tetrahydrofuran
3: manganese(IV) dioxide / ethanol
View Scheme
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
反应条件
1: DIPEA / palladium monocarbide / ethanol
2: LiAlH4 / tetrahydrofuran
3: manganese(IV) dioxide / ethanol
View Scheme
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
反应条件
1: K2CO3, 18-crown-6 / acetone / Heating
2: 34 percent / Bu3SnH, AIBN / benzene / 1 h / Heating
View Scheme
参考文献
Lee, Eun; Lee, Chulbom; Tae, Jin Sung; Whang, Ho Sung; Li, Kap Sok
Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2343 - 2346
反应条件
1: LiAlH4 / tetrahydrofuran
2: manganese(IV) dioxide / ethanol
View Scheme
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
