1,1,1,2-四氟乙烷合成路线 （共 120 条）
反应条件
n-butyllithium in diethyl ether
T=-78°C;
参考文献
Banger, Kulbinder K.; Brisdon, Alan K.; Gupta, Arti
Chemical Communications, 1997 , # 1 p. 139 - 140
反应条件
1: 1,1,1-trifluoro-2-fluoroethane With zinc(II) chloride; lithium diisopropyl amide in tetrahydrofuran
T=15 - 20°C; 1 h;
2: para-iodoanisole With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=60°C; 1 h;
参考文献
Raghavanpillai, Anilkumar; Burton, Donald J.
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7083 - 7091
反应条件
1: 1,1,1-trifluoro-2-fluoroethane With zinc(II) chloride; lithium diisopropyl amide in tetrahydrofuran
T=15 - 20°C;
2: 1-chloro-4-iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=60°C; 2 h;
参考文献
Raghavanpillai, Anilkumar; Burton, Donald J.
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7083 - 7091
反应条件
1: 1,1,1-trifluoro-2-fluoroethane With zinc(II) chloride; lithium diisopropyl amide in tetrahydrofuran
T=15 - 20°C;
2: para-nitro iodo-benzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=60°C; 1 h;
参考文献
Raghavanpillai, Anilkumar; Burton, Donald J.
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7083 - 7091
反应条件
potassium hydroxide in dimethyl sulfoxide
T=60°C; 22 h;
参考文献
Wu, Kai; Chen, Qing-Yun
Tetrahedron, 2002 , vol. 58, # 20 p. 4077 - 4084
反应条件
1: 1,1,1-trifluoro-2-fluoroethane With zinc(II) chloride; lithium diisopropyl amide in tetrahydrofuran
T=15 - 20°C;
2: 4-trifluoromethyl-1-iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=65°C; 1.5 h;
参考文献
Raghavanpillai, Anilkumar; Burton, Donald J.
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7083 - 7091
反应条件
1: 1,1,1-trifluoro-2-fluoroethane With zinc(II) chloride; lithium diisopropyl amide in tetrahydrofuran
T=15 - 20°C;
2: 1-chloro-3-iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=65°C; 2 h;
参考文献
Raghavanpillai, Anilkumar; Burton, Donald J.
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7083 - 7091
反应条件
n-butyllithium in diethyl ether
T=-80 - 20°C;
参考文献
Barnes, Nicholas A.; Brisdon, Alan K.; Brown, F. R. William; Cross, Wendy I.; Crossley, Ian R.; Fish, Cheryl; Morey, James V.; Pritchard, Robin G.; Sekhri, Lakhdar
New Journal of Chemistry, 2004 , vol. 28, # 7 p. 828 - 837
反应条件
potassium hydroxide in dimethyl sulfoxide
T=60°C; 24 h;
参考文献
Wu, Kai; Chen, Qing-Yun
Tetrahedron, 2002 , vol. 58, # 20 p. 4077 - 4084
反应条件
in further solvent(s)
Kinetics; Electrochem. Process; electrolysis on Pt or Pb electodes with 0.1 M TBABF4 at 60-80°C and 260 bar;
参考文献
Abbott, Andrew P.; Eardley, Christopher A.
Journal of Physical Chemistry B, 2000 , vol. 104, # 4 p. 775 - 779
