sodium hydroxide in methanol 0.5 h; Heating;

1: 94.2 percent / 40percent aq. NaOH / methanol / 0.5 h / Heating 2: 81.7 percent / H2O; acetic acid / 48 h / Ambient temperature 3: 81.8 percent / DMF / H2O / 1 h / Heating 4: 87.6 percent / 40percent aq. NaOH / methanol / 2 h / Heating View Scheme

1: 94.2 percent / 40percent aq. NaOH / methanol / 0.5 h / Heating 2: 81.7 percent / H2O; acetic acid / 48 h / Ambient temperature 3: 81.8 percent / DMF / H2O / 1 h / Heating View Scheme

1: 94.2 percent / 40percent aq. NaOH / methanol / 0.5 h / Heating 2: 81.7 percent / H2O; acetic acid / 48 h / Ambient temperature View Scheme

Multi-step reaction with 3 steps 1: 92.5 percent / titanium(III) chloride / methanol; H2O / 0.12 h / Ambient temperature2: 1.) NaNO2, HCl, 2.) NaBF4 / 1.) water,5 deg C, 20 min. 2.) water, 0 deg C, 20 min; room temp., 30 min3: 50.6 percent / SiO2 / neat (no solvent) / 0.33 h / 175 - 180 °C