1: 1) LiN(i-Pr)2, HMPT / 1) -70 deg C, THF, 2) -70 to 0 deg C, 10 min 2: KOH / H2O; methanol / 0.17 h / 60 °C / e.e.: 85percent View Scheme

1: 95 percent / LDA 2: 60 percent / 650 °C / 0.01 Torr View Scheme

1: 60 percent / LDA / tetrahydrofuran / 1 h / -78 °C 2: 70 percent / diisopropylethylamine / acetonitrile / Heating 3: 97 percent / KOH / ethanol; H2O 4: 62 percent / O2; t-Bu-CHO / Co(III) ortho-phenylene-bis(N'-methyloxamidate) complex 5: 85 percent / TiCl4 View Scheme

1.1: LDA; HMPA / heptane; tetrahydrofuran; ethylbenzene / -78 °C 1.2: 30 percent / HMPA / heptane; tetrahydrofuran; ethylbenzene / -78 °C 2.1: 94 percent / KOH / ethanol / 20 °C 3.1: 82 percent / O2; pivalaldehyde; substituted o-phenylenediamine Co(III) complex / acetonitrile View Scheme

1: 1) LiN(i-Pr)2, HMPT / 1) -70 deg C, THF, 2) -70 to 0 deg C, 10 min 2: KOH / H2O; methanol / 0.17 h / 60 °C / e.e.: 85percent View Scheme

1.1: LDA; HMPA / heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C 1.2: 37 percent / HMPA / heptane; tetrahydrofuran; ethylbenzene / 0.17 h / -78 °C 2.1: 78 percent / KOH / ethanol / 20 °C 3.1: 90 percent / O2; pivalaldehyde; substituted o-phenylenediamine Co(III) complex / acetonitrile View Scheme

1.1: LDA; HMPA / heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C 1.2: 75 percent / HMPA / heptane; tetrahydrofuran; ethylbenzene / 0.17 h / -78 °C 2.1: 93 percent / KOH / ethanol / 20 °C 3.1: 80 percent / O2; pivalaldehyde; substituted o-phenylenediamine Co(III) complex / acetonitrile View Scheme

1.1: LDA; HMPA / heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C 1.2: 90 percent / HMPA / heptane; tetrahydrofuran; ethylbenzene / 0.17 h / -78 °C 2.1: KOH / ethanol / 20 °C 2.2: 63 percent / aq. HCl / ethanol View Scheme