1-(3,5-二-o-乙酰基-beta-d-呋喃核糖)-4-(1,2,4-噻唑-l-基)-5-甲基-2-嘧啶酮合成路线 （共 12 条）
参考文献
Birnbaum, George I.; Sadana, Krishan L.; Blonski, Wayne J. P.; Hruska, Frank E.
Journal of the American Chemical Society, 1986 , vol. 108, # 7 p. 1671 - 1675
反应条件
ammonium hydroxide in 1,4-dioxane Ambient temperature;
参考文献
Sung, Wing L.
Journal of the Chemical Society, Chemical Communications, 1981 , # 20 p. 1089
反应条件
1: 1H-1,2,4-triazol With trichlorophosphate in acetonitrile
T=0°C; 0.166667 h;
2: With triethylamine in acetonitrile
T=0°C; 0.333333 h;
3: 3',5'-diacetylthymidine in acetonitrile
T=20°C; Further stages.;
参考文献
Felczak; Miazga; Poznanski; Bretner; Kulikowski; Dzik; Golos; Zielinski; Ciesla; Rode
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4647 - 4656
反应条件
triethylamine in tetrahydrofuran
参考文献
Reese, Colin B.; Richards, Keith H.
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2245 - 2248
反应条件
triethylamine in tetrahydrofuran
参考文献
Reese, Colin B.; Richards, Keith H.
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2245 - 2248
反应条件
in acetonitrile
3 h;
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, # 2 p. 99 - 104
反应条件
1: pyridine
2: POCl3, TEA / acetonitrile
View Scheme
参考文献
Rodriguez-Tanty; Higginson-Clarke; Hernandez; Perez; Velez- Castro; Riveron; Macias
Nucleosides and Nucleotides, 1997 , vol. 16, # 4 p. 455 - 467
反应条件
1: 57 percent / 1-methylimidazole / pyridine / 24 h / 50 °C
2: 68 percent / triethylamine / tetrahydrofuran
View Scheme
参考文献
Reese, Colin B.; Richards, Keith H.
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2245 - 2248
反应条件
1-methyl-1H-imidazole in tetrahydrofuran
360 h; Ambient temperature;
参考文献
Reese, Colin B.; Richards, Keith H.
Tetrahedron Letters, 1985 , vol. 26, # 18 p. 2245 - 2248
反应条件
pyridine
T=20°C; Substitution;
参考文献
Wallis, Mark P.; Mahmood, Naheed; Fraser, William
Farmaco, 1999 , vol. 54, # 1-2 p. 83 - 89
