(E)-4-(3,4-二甲氧基苯基)-4-氧代-2-丁烯酸乙酯合成路线 （共 5 条）
反应条件
1: maleic anhydride With AlCl3, aluminium chloride in chlorobenzene T=10°C; 2: 1,2-dimethoxy-benzene in chlorobenzene T=10 - 30°C; 48 h; Product distribution / selectivity;
参考文献
Sankio Chemical Co., Ltd.; Meiji Seika Kaisha, Ltd.
Patent: EP1505054 A1, 2005 ;
Location in patent: Page/Page column 9-11 ;
反应条件
trimethylsilyl iodide in chlorobenzene Heating / reflux;
参考文献
EP1505054 A1, ;
Page/Page column 24 ;
反应条件
aluminium trichloride in chlorobenzene T=50 - 55°C; Friedel-Crafts reaction; 14 h;
参考文献
Chemistry Letters, , vol. 35, # 1 p. 22 - 23
反应条件
in acetic acid 20 h; Heating;
参考文献
Bianchi, Mario; Butti, Alina; Christidis, Yani; Perronnet, Jacques; Barzaghi, Fernando; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 45 - 52
