2-(4-溴苯基)-2-甲基-环氧乙烷合成路线 （共 12 条）
反应条件
1: trimethyloxosulfonium iodide With sodium hydride in tetrahydrofuran; mineral oil
T=70°C; 1 h; Inert atmosphere;
2: para-bromoacetophenone in tetrahydrofuran; mineral oil
48 h; Inert atmosphere;
参考文献
Theodorou, Alexis; Papadopoulos, Giorgos N.; Kokotos, Christoforos G.
Tetrahedron, 2013 , vol. 69, # 26 p. 5438 - 5443
反应条件
potassium tert-butylate in dimethyl sulfoxide
T=20°C; Inert atmosphere;
参考文献
Molinaro, Carmela; Guilbault, Audrey-Anne; Kosjek, Birgit
Organic Letters, 2010 , vol. 12, # 17 p. 3772 - 3775
反应条件
methyllithium in tetrahydrofuran; diethyl ether
T=0 - 20°C;
参考文献
GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT
Patent: WO2009/120789 A1, 2009 ;
Location in patent: Page/Page column 99 ;
反应条件
3,3-dimethyldioxirane
参考文献
Suprun, Wladimir
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 3 p. 231 - 237
反应条件
potassium tert-butylate in neat (no solvent)
T=70°C; 5 h; kugelrohr distillation at the end of reaction;
参考文献
Toda, Fumio; Kanemoto, Kazuyuki
Heterocycles, 1997 , vol. 46, # 1 p. 185 - 188
反应条件
in dimethyl sulfoxide
T=20°C; Addition; 12.5 h;
参考文献
Cleij; Archelas; Furstoss
Journal of Organic Chemistry, 1999 , vol. 64, # 14 p. 5029 - 5035
反应条件
1: 81 percent / TsOH / benzene / Heating
2: 85 percent / dimethyldioxirane
View Scheme
参考文献
Suprun, Wladimir
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 3 p. 231 - 237
反应条件
sodium hydride in tetrahydrofuran; dimethyl sulfoxide
T=0°C;
参考文献
Tan, Chong Kiat; Er, Jun Cheng; Yeung, Ying-Yeung
Tetrahedron Letters, 2014 , vol. 55, # 6 p. 1243 - 1246
反应条件
oxygen in chlorobenzene
T=95°C; P=757.6 Torr; var. of temp., further addition of cumene, ΔEa; Product distributionKineticsThermodynamic data;
参考文献
Suprun, Wladimir
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 3 p. 231 - 237
反应条件
potassium hydroxide in methanol
0.0833333 h;
参考文献
Crombie, Leslie; Hardy, Robert; Knight, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1373 - 1380
