3-(2-氟苯基)-5-异噁唑羧醛合成路线 （共 3 条）
反应条件
pyridinium chlorochromate in dichloromethane T=20°C; 4 h;
参考文献
NEUROMED PHARMACEUTICALS LTD.
Patent: WO2007/118323 A1, 2007 ;
Location in patent: Page/Page column 26-27 ;
WO 2007/118323 A1
反应条件
1.1: N-chlorosuccinimide; pyridine / tetrahydrofuran / 0.5 h / 60 °C 1.2: triethylamine / tetrahydrofuran / 2 h / 50 °C 2.1: pyridinium chlorochromate; silica gel / CH2Cl2 / 5 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 15 p. 3965 - 3970
反应条件
1.1: NH2OH*HCl; Na2CO3 / ethanol; H2O / 1 h / 60 °C 2.1: N-chlorosuccinimide; pyridine / tetrahydrofuran / 0.5 h / 60 °C 2.2: triethylamine / tetrahydrofuran / 2 h / 50 °C 3.1: pyridinium chlorochromate; silica gel / CH2Cl2 / 5 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 15 p. 3965 - 3970
