4-氯甲基-5-甲基-1,3-二氧杂环戊烯-2-酮合成路线 （共 22 条）
反应条件
1: With formic acid; triethylamine in acetonitrile T=10 - 65°C; 2: With hydrogenchloride in isopropyl alcohol Reflux; Product distribution / selectivity;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BANSAL, Deepak; MISHRA, Himanchal; DUBEY, Shailendr, Kumar; CHOUDHARY, Alka, Srivastava; VIR, Dharam; AGARWAL, Ashutosh
Patent: WO2012/107814 A1, 2012 ;
Location in patent: Page/Page column 14-15 ;
反应条件
sodium bromide in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
CIPLA LIMITED; PATHI, Srinivas Laxminarayan; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra; CHINIMILLI, Venugopalarao; CURTIS, Philip Anthony
Patent: WO2012/1357 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
1: in N,N-dimethyl-formamide T=20°C; 12 h; 2: With hydrogenchloride in chloroform; water
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2005/187269 A1, 2005 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1.1: triethylamine; formic acid / acetonitrile / 10 - 65 °C 1.2: Reflux 2.1: 4-(N,N-dimethlyamino)pyridine; potassium carbonate; p-toluoylsulfonylchloride / isobutyramide / -15 - 25 °C 2.2: 0.5 h / pH 4 - 5 View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; BANSAL, Deepak; MISHRA, Himanchal; DUBEY, Shailendr, Kumar; CHOUDHARY, Alka, Srivastava; VIR, Dharam; AGARWAL, Ashutosh
Patent: WO2012/107814 A1, 2012 ;
反应条件
N-ethyl-N,N-diisopropylamine; sodium bromide 1.) DMF, 303 K, 2 h, 2.) DMF, 304 K, 1 h; Yield given. Multistep reaction;
参考文献
Fujii; Nishida; Abiru; Yamamoto; Kise
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 11 p. 1872 - 1877
反应条件
1: trityl olmesartan medoxomil With hydrogenchloride; ethanol; water T=24 - 26°C; 3 h; 2: medoxomil chloride With sodium hydroxide in ethanol; water pH=5; 0.25 h;
参考文献
KRKA
Patent: WO2007/17135 A2, 2007 ;
Location in patent: Page/Page column 5; 21-22 ;
反应条件
1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 3 h / 0 - 45 °C 2: hydrogenchloride; water / ethyl acetate; methanol / 2 h / 20 °C View Scheme
参考文献
Krka Tovarna Zdravil, D.D., Novo Mesto; ZUPANCIC, Silvo
Patent: EP2334668 B1, 2014 ;
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl acetamide T=0 - 45°C; 3 h;
参考文献
Krka Tovarna Zdravil, D.D., Novo Mesto; ZUPANCIC, Silvo
Patent: EP2334668 B1, 2014 ;
Location in patent: Paragraph 0079-0080 ;
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl acetamide T=0 - 45°C; 3 h; Inert atmosphere;
参考文献
Krka Tovarna Zdravil, D.D., Novo Mesto; ZUPANCIC, Silvo
Patent: EP2334668 B1, 2014 ;
Location in patent: Paragraph 0077-0078 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl acetamide T=40 - 65°C; 5 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED; CURTIS, Philip, Anthony
Patent: WO2008/43996 A2, 2008 ;
Location in patent: Page/Page column 18-19 ;
