2-氨基-2’-O-甲基腺苷合成路线 （共 5 条）
反应条件
1: 2,6-Diamino-9-(β-D-ribofuranosyl)-purine With tin(ll) chloride in N,N-dimethyl-formamide T=50°C; 0.25 h; 2: diazomethane in N,N-dimethyl-formamide T=50°C; Title compound not separated from byproducts;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 25, # 3 p. 307 - 314
反应条件
1: 2,6-Diamino-9-(β-D-ribofuranosyl)-purine With tin(ll) chloride in N,N-dimethyl-formamide T=20°C; 0.166667 h; 2: diazomethane in N,N-dimethyl-formamide T=50°C;
参考文献
Kore, Anilkumar; Parmar, Gaurang; Reddy, Srinu
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 3 p. 307 - 314
反应条件
1: 1.) hexamethyldisilazane, chlorotrimethylsilane; 2.) hexamethyldisilazane, CF3SO3SiMe3, NH3 / 1.) reflux, 16 h; 2.) 150 deg C, 3 d (sealed bomb) 2: 51 percent / SnCl2*2H2O / dimethylformamide; 1,2-dimethoxy-ethane / 50 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 59, p. 3360 - 3364
反应条件
calf spleen adenosine deaminase; sodium salt of phosphorous acid in dimethyl sulfoxide T=20°C; pH=7.4; 36 h;
参考文献
Kore, Anilkumar; Parmar, Gaurang; Reddy, Srinu
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 3 p. 307 - 314
反应条件
in dimethyl sulfoxide
参考文献
Isis Pharmceuticals, Inc.
Patent: US5646265 A1, 1997 ;
