二氯(1-甲基乙基)-镁酸锂盐合成路线 （共 11 条）
反应条件
lithium chloride in tetrahydrofuran T=23°C; 72 h;
参考文献
US2008/45511 A1, ;
Page/Page column 24 ;
反应条件
in tetrahydrofuran T=20°C; 12 h;
参考文献
EP1582523 A1, ;
Page/Page column 10 ;
反应条件
in tetrahydrofuran T=20°C; 1 h; Product distribution / selectivity;
参考文献
WO2010/97410 A1, ;
Page/Page column 117 ;
反应条件
in tetrahydrofuran T=-20°C;
参考文献
Liang, Yu-Feng; Jiao, Ning
Angewandte Chemie - International Edition, 2014 , vol. 53, # 2 p. 548 - 552
Angew. Chem., 2014 , vol. 53, # 2 p. 558 - 562,5
反应条件
in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Thomas, Andrew
Patent: US2009/143385 A1, 2009 ;
反应条件
1: isopropylmagnesium chloride lithium chloride complex With 2,2,6,6-tetramethyl-piperidine in tetrahydrofuran Inert atmosphere; 2: benzaldehyde Inert atmosphere;
参考文献
Rohbogner, Christoph J.; Wirth, Stefan; Knochel, Paul
Organic Letters, 2010 , vol. 12, # 9 p. 1984 - 1987
反应条件
in tetrahydrofuran
T=-20 - 20°C;
参考文献
Li, Zhou; Gevorgyan, Vladimir
Angewandte Chemie - International Edition, 2011 , vol. 50, # 12 p. 2808 - 2810
反应条件
ammonium chloride in tetrahydrofuran
iPrMgCl*LiCl in THF added to soln. at -78°C of C5H3NI2 in THF in dry, argon-flushed Schlenk tube; mixt. stirred for 2 h, until I/Mg exchange; BO2(C(CH3)2)2(OCH3) added; allowed to warm to room. temp., 1 h; quenched with aq. soln. of NH4Cl; extrn. with Et2O; dried over Na2SO4; filtration, soln. evapd. in vac.;
参考文献
Baron, Oliver; Knochel, Paul
Angewandte Chemie - International Edition, 2005 , vol. 44, # 20 p. 3133 - 3135
反应条件
1: 3-bromo-pyridine With boron trifluoride diethyl etherate in tetrahydrofuran
T=0°C; 0.25 h; Inert atmosphere;
2: isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran
T=-50°C; 0.5 h; Inert atmosphere;
3: With chloranil in tetrahydrofuran
T=20°C; 2 h; Inert atmosphere; regioselective reaction;
参考文献
Chen, Quan; Du Jourdin, Xavier Mollat; Knochel, Paul
Journal of the American Chemical Society, 2013 , vol. 135, # 13 p. 4958 - 4961
反应条件
T=20°C; 3 h; Product distribution / selectivity;
参考文献
Ludwig-Maximilians-Universitaet Muenchen
Patent: EP1582523 A1, 2005 ;
Location in patent: Figure 3 ;
