1: 74 percent / Et3N / diethyl ether / 1 h / Ambient temperature 2: 84.6 percent / H2 / 5percent Pd/C / dimethylformamide / 3 h / 2585.7 Torr 3: SOCl2, DMF / toluene / Ambient temperature 4: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C 5: acetonitrile / 2 h / 120 °C 6: various solvent(s) / 0.42 h / 220 - 230 °C View Scheme

1: ethanol; H2O / 130 °C 2: 74 percent / Et3N / diethyl ether / 1 h / Ambient temperature 3: 84.6 percent / H2 / 5percent Pd/C / dimethylformamide / 3 h / 2585.7 Torr 4: SOCl2, DMF / toluene / Ambient temperature 5: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C 6: acetonitrile / 2 h / 120 °C 7: various solvent(s) / 0.42 h / 220 - 230 °C View Scheme

1: 84.6 percent / H2 / 5percent Pd/C / dimethylformamide / 3 h / 2585.7 Torr 2: SOCl2, DMF / toluene / Ambient temperature 3: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C 4: acetonitrile / 2 h / 120 °C 5: various solvent(s) / 0.42 h / 220 - 230 °C View Scheme

1: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C 2: acetonitrile / 2 h / 120 °C 3: various solvent(s) / 0.42 h / 220 - 230 °C View Scheme

1: SOCl2, DMF / toluene / Ambient temperature 2: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C 3: acetonitrile / 2 h / 120 °C 4: various solvent(s) / 0.42 h / 220 - 230 °C View Scheme

1: acetonitrile / 2 h / 120 °C 2: various solvent(s) / 0.42 h / 220 - 230 °C View Scheme