(R)-(-)-2-氨基-1-戊醇合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Calter, Michael; Hollis, T. Keith; Overman, Larry E.; Ziller, Joseph; Zipp, G. Greg
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1449 - 1456
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 59 ;
反应条件
1: pyridine / 2.5 h / 0 °C
2: 16.4 g / sodium hydroxide / diethyl ether; H2O / 1.5 h / 0 °C
View Scheme
参考文献
Oka, Takahiro; Yasusa, Takuya; Ando, Takashi; Watanabe, Mayumi; Yoneda, Fumio; Ishida, Toshimasa; Knoll, Joseph
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1213 - 1219
反应条件
1: With triethylamine in dichloromethane
2: With sodium hydroxide in tetrahydrofuran; dichloromethane
参考文献
Kim, Haejin; Rhee, Young Ho
Journal of the American Chemical Society, 2012 , vol. 134, # 9 p. 4011 - 4014
