1,3-苯并二氧戊环-5-基甲酸酯合成路线 （共 13 条）
反应条件
1: 10percent aq. KOH / methanol / 2.5 h / Ambient temperature
2: 56 percent / CF3COOH / 4 h / Heating
View Scheme
参考文献
Saito, Naoki; Tashiro, Kyoichi; Maru, Yukie; Yamaguchi, Kentaro; Kubo, Akinori
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1997 , # 1 p. 53 - 70
反应条件
1.1: potassium hydroxide / methanol; H2O
2.1: 4.7 g / ethyldiisopropylamine / CH2Cl2 / 0 - 20 °C
3.1: n-butyl lithium / tetrahydrofuran; hexane / 0.17 h / -78 °C
3.2: 90 percent / tetramethylethylenediamine / tetrahydrofuran; hexane / 12 h / -78 - 20 °C
4.1: HCl / ethanol / Heating
5.1: 3.0 g / potassium carbonate / acetone / 5 h / Heating
View Scheme
参考文献
Chandrasekhar; Reddy, N. Ramakrishna; Rao, Y. Srinivasa
Tetrahedron, 2006 , vol. 62, # 51 p. 12098 - 12107
反应条件
1: methanolic KOH / methanol; tetrahydrofuran / 30 h / 10 °C
2: 1) ignited potassium carbonate, 2) ignited NaI
View Scheme
参考文献
Rohatgi, B. K.; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 11 p. 1150
