1,3-苯并二氧戊环-5-基甲酸酯合成路线 （共 13 条）
反应条件
1: potassium hydroxide / methanol; H2O 2: 4.7 g / ethyldiisopropylamine / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Saito, Naoki; Tashiro, Kyoichi; Maru, Yukie; Yamaguchi, Kentaro; Kubo, Akinori
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1997 , # 1 p. 53 - 70
反应条件
1: 10percent aq. KOH / methanol / 2.5 h / Ambient temperature 2: 99 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 3 h 3: 72 percent / BuLi / tetrahydrofuran / 1.) -17 deg C, 1 h, 2.) -17 deg C, 2 h 4: 77 percent / conc. aq. HCl / ethanol / 3 h / Heating 5: 73 percent / acetic acid / 0.5 h / Heating View Scheme
参考文献
Saito, Naoki; Tashiro, Kyoichi; Maru, Yukie; Yamaguchi, Kentaro; Kubo, Akinori
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1997 , # 1 p. 53 - 70
反应条件
1.1: potassium hydroxide / methanol; H2O 2.1: 4.7 g / ethyldiisopropylamine / CH2Cl2 / 0 - 20 °C 3.1: n-butyl lithium / tetrahydrofuran; hexane / 0.17 h / -78 °C 3.2: 90 percent / tetramethylethylenediamine / tetrahydrofuran; hexane / 12 h / -78 - 20 °C View Scheme
参考文献
Saito, Naoki; Tashiro, Kyoichi; Maru, Yukie; Yamaguchi, Kentaro; Kubo, Akinori
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1997 , # 1 p. 53 - 70
反应条件
ethanol; sodium hydroxide T=82 - 96°C; 4.5 h; Reflux; elimination of ethyl formate;
参考文献
DAICEL CHEMICAL INDUSTRIES, Ltd.
Patent: EP1167365 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
water; potassium hydroxide in methanol T=50°C; 1 h;
参考文献
Singh, Pragya; Faridi, Uzma; Srivastava, Suchita; Kumar, Jonnala Kotesh; Darokar, Mahender Pandurang; Luqman, Suaib; Shanker, Karuna; Chanotiya, Chandan Singh; Gupta, Atul; Gupta, Madan Mohan; Negi, Arvind Singh
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 2 p. 242 - 246
反应条件
ethanol; sodium hydroxide T=82 - 96°C; 4.5 h; Reflux; elimination of ethyl formate;
参考文献
DAICEL CHEMICAL INDUSTRIES, Ltd.
Patent: EP1167365 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
Ambient temperature;
参考文献
Camps, F.; Coll, J.; Messeguer, A.; Pericas, M.A.
Tetrahedron Letters, 1981 , vol. 22, # 39 p. 3895 - 3896
反应条件
peracetic acid in ethyl acetate
T=50°C; 8 h;
参考文献
DAICEL CHEMICAL INDUSTRIES, Ltd.
Patent: EP1167365 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
1: With peracetic acid in ethyl acetate
T=40°C; 5 h;
2: boiling, elimination of ethyl fprmate;
参考文献
DAICEL CHEMICAL INDUSTRIES, Ltd.
Patent: EP1167365 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
hydrogen peroxide in water
T=50°C; 2 h; Acidic conditions;
参考文献
DAICEL CHEMICAL INDUSTRIES, Ltd.
Patent: EP1167365 A1, 2002 ;
Location in patent: Page 5 ;
