2-甲基吡唑并[1,5-a]吡啶-3-羧酸合成路线 （共 2 条）
反应条件
sodium hydroxide
1) water, 30 min, reflux, 2) 95percent ethanol, 20 min, reflux, 3) HCl;
参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=0 - 20°C; 72 h;
2: With water; sodium hydroxide in methanol
T=70°C; 1 h;
参考文献
PTC THERAPEUTICS, INC.; LEE, Chang-Sun; BAIAZITOV, Ramil; CAO, Liangxian; DAVIS, Thomas, W.; DU, Wu; LIU, Ronggang; MOON, Young-choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald
Patent: WO2014/81906 A2, 2014 ;
Location in patent: Page/Page column 162 ;
