4-(苯并[d][1,3]二氧代l-5-甲基)二氢呋喃-2(3H)-酮合成路线 （共 23 条）
反应条件
hydrogenchloride; lithium methanolate; hydrogen; palladium on activated charcoal
1) MeOH, reflux; 2) MeOH, room temperature; 3) THF, room temperature; 4) EtOAc, room temperature; Multistep reaction;
参考文献
Kawai; Hasegawa; Gotoh; Ohashi
Phytochemistry, 1994 , vol. 37, # 6 p. 1699 - 1702
反应条件
1: 84 percent / CuCN
2: 91 percent / aq. OsO4; NMO / acetonitrile; tetrahydrofuran
3: aq. KIO4 / acetonitrile; tetrahydrofuran / 9 h / 35 °C
4: NaBH4
5: Bu4NF
6: aq. KIO4 / acetonitrile; tetrahydrofuran / 35 °C
7: 93 percent / PCC; NaOAc
View Scheme
参考文献
Isemori, Yuichi; Kobayashi, Yuichi
Synlett, 2004 , # 11 p. 1941 - 1944
反应条件
potassium hydroxide; calcium tetrahydridoborate
1.) H2O, 2.) ethanol, 10 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Brown, Eric; Robin, Jean-Pierre; Dhal, Robert
Tetrahedron, 1982 , vol. 38, # 16 p. 2569 - 2580
