(R)-1-(4-溴苯基)-2,2,2-三氟乙醇合成路线 （共 11 条）
反应条件
sodium tetrahydroborate; sodium hydroxide in methanol T=20°C; 1.5 h;
参考文献
Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M.J.M.; Menard, Delphine; Zambon, Alfonso; Davies, Lawrence; Pons, Jean-Francois; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1284 - 1304
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h; 2: With water in N,N-dimethyl-formamide 4 h; Acidic conditions;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
cesium fluoride in tetrahydrofuran 20 h; Heating;
参考文献
Motherwell, William B.; Storey, Lynda J.
Journal of Fluorine Chemistry, 2005 , vol. 126, # 4 p. 491 - 498
反应条件
1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2Λ54Λ5-catenadi(phosphazene) in tetrahydrofuran; hexane T=-30°C; 2 h; Schlenk techniqueInert atmosphere;
参考文献
Kawai, Hiroyuki; Yuan, Zhe; Tokunaga, Etsuko; Shibata, Norio
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 9 p. 1446 - 1450
反应条件
1: 2,2,2-trifluoroethane-1,1-diol With potassium tert-butylate in N,N-dimethyl-formamide T=-50°C; 0.583333 h; 2: 4-bromo-benzaldehyde in N,N-dimethyl-formamide T=-50°C; 1 h;
参考文献
Surya Prakash; Zhang, Zhe; Wang, Fang; Munoz, Socrates; Olah, George A.
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3300 - 3305
反应条件
phenolated sodium in N,N-dimethyl-formamide T=0°C; 6.5 h;
参考文献
Shen, Xiao; Zhou, Min; Ni, Chuanfa; Zhang, Wei; Hu, Jinbo
Chemical Science, 2013 , vol. 5, # 1 p. 117 - 122
反应条件
1: cesium fluoride / tetrahydrofuran / 9 h / 20 °C 2: ammonium chloride; water / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 15 p. 7749 - 7753
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate 20 h; Reflux;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
sodium hydride
1) ether, 1 h; 2) ether, 4 h; Multistep reaction;
参考文献
Allen, Annette D.; Ambidge, I. Christopher; Che, Claudius; Micheal, Hany; Muir, Ronald J.; Tidwell, Thomas T.
Journal of the American Chemical Society, 1983 , vol. 105, # 8 p. 2343 - 2350
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide
T=85°C; 2.41667 h;
参考文献
Gauthier, Jacques Yves; Li, Chun Sing; Mellon, Christophe
Patent: US2006/111440 A1, 2006 ;
Location in patent: Page/Page column 18 ;
US 20060111440 A1
