(S)-1-(2-硝基苯基)乙醇合成路线 （共 6 条）
反应条件
1: 62 percent / Et3N / tetrahydrofuran / -78 - 0 °C 2: tetrazole / acetonitrile 3: I2, pyridine, water / CH2Cl2 4: 56 percent / TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 7 p. 711 - 714
反应条件
triethylamine in tetrahydrofuran T=-20 - 20°C; Condensation;
参考文献
Scheigetz, John; Roy, Bruno
Synthetic Communications, 2000 , vol. 30, # 8 p. 1437 - 1445
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; iron(III) chloride in water; ethyl acetate T=20°C; 10 h;
参考文献
Kumar, R. Senthil; Karthikeyan; Perumal, Paramasivan T.
Canadian Journal of Chemistry, 2008 , vol. 86, # 7 p. 720 - 725
反应条件
methyllithium 1.) THF, ether, RT, 4 h, 2.) THF, reflux, 10 h; Yield given. Multistep reaction;
参考文献
Cameron, James F.; Frechet, Jean M. J.
Journal of the American Chemical Society, 1991 , vol. 113, # 11 p. 4303 - 4313
反应条件
1: 62 percent / Et3N / tetrahydrofuran / -78 - 0 °C
2: tetrazole / acetonitrile
3: I2, pyridine, water / CH2Cl2
4: 56 percent / TFA / CH2Cl2
5: CDCl3 / 48 h / Irradiation
View Scheme
参考文献
Qiao, Lixin; Kozikowski, Alan P.; Olivera, Ana; Spiegel, Sarah
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 711 - 714
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Su, Meng; Wang, Jie; Tang, Xinjing
Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9628 - 9637
