1: acetic acid; ethanol; H2O / 6 h / Heating 2: 1.) Cu(OAc)2, 2.) pyridine / 1.) THF, water, reflux, 30 min, 2.) water View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587204', constants.ctx, '0')">tert.-butyl lithium</a> <br />&nbsp;1.) THF, pentane, from -78 deg C to -25 deg C, 1.5 h, 2.) from -78 deg C to RT, 2 h;&nbsp;&nbsp;Multistep reaction;&nbsp;<br /> &nbsp;