2,3-二氢-5-甲氧基-1H-茚-1-乙酸合成路线 （共 10 条）
反应条件
1: With lithium hydroxide hydrate; water in 1,4-dioxane
T=20°C;
2: With hydrogenchloride in water
pH=1;
参考文献
Schering Corporation
Patent: US2011/312995 A1, 2011 ;
Location in patent: Page/Page column 46 ;
反应条件
potassium hydroxide in water; ethylene glycol
T=130°C; 10 h;
参考文献
Basu, Basudeb; Maity, Sanat K.; Mukherjee, Debabrata
Synthetic Communications, 1981 , vol. 11, # 10 p. 803 - 810
反应条件
1: 80 percent / NH4OAc
2: 88 percent / NaBH4 / tetrahydrofuran; ethanol / 0 °C
3: 72 percent / LiCl / dimethylsulfoxide / 5 h / 180 °C
4: 85 percent / 8percent KOH / H2O; ethane-1,2-diol / 10 h / 130 °C
View Scheme
参考文献
Basu, Basudeb; Maity, Sanat K.; Mukherjee, Debabrata
Synthetic Communications, 1981 , vol. 11, # 10 p. 803 - 810
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethanol / 20 °C
2.1: water; lithium hydroxide hydrate / 1,4-dioxane / 20 °C
2.2: pH 1
View Scheme
参考文献
Schering Corporation
Patent: US2011/312995 A1, 2011 ;
反应条件
1: 72 percent / LiCl / dimethylsulfoxide / 5 h / 180 °C
2: 85 percent / 8percent KOH / H2O; ethane-1,2-diol / 10 h / 130 °C
View Scheme
参考文献
Basu, Basudeb; Maity, Sanat K.; Mukherjee, Debabrata
Synthetic Communications, 1981 , vol. 11, # 10 p. 803 - 810
反应条件
hydrogenchloride; Zn–Hg amalgam in benzene
Heating;
参考文献
Pramanik; Mukherjee
Journal of the Indian Chemical Society, 1997 , vol. 74, # 9 p. 734 - 735
反应条件
1: polyphosphoric acid / Heating
2: zinc amalgam, aq. HCl / benzene / Heating
View Scheme
参考文献
Pramanik; Mukherjee
Journal of the Indian Chemical Society, 1997 , vol. 74, # 9 p. 734 - 735
反应条件
1: KOH / ethanol / Heating
2: polyphosphoric acid / Heating
3: zinc amalgam, aq. HCl / benzene / Heating
View Scheme
参考文献
Pramanik; Mukherjee
Journal of the Indian Chemical Society, 1997 , vol. 74, # 9 p. 734 - 735
反应条件
1: piperidine / 72 h / 30 - 40 °C
2: KOH / ethanol / Heating
3: polyphosphoric acid / Heating
4: zinc amalgam, aq. HCl / benzene / Heating
View Scheme
参考文献
Pramanik; Mukherjee
Journal of the Indian Chemical Society, 1997 , vol. 74, # 9 p. 734 - 735
反应条件
potassium hydroxide; sodium amalgam
参考文献
Novak; Protiva
Collection of Czechoslovak Chemical Communications, 1958 , vol. 23, p. 663,666, 671
