6-甲基-3-吡啶胺离子合成路线 （共 26 条）
反应条件
1: 5-Amino-2-methylpyridine; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With tert.-butylnitrite in acetonitrile T=80°C; 2 h; 2: iodobenzene With tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide T=100°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Qiu, Di; Jin, Liang; Zheng, Zhitong; Meng, He; Mo, Fanyang; Wang, Xi; Zhang, Yan; Wang, Jianbo
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1923 - 1933
反应条件
1: 5-Amino-2-methylpyridine With lithium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.25 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 17 h;
参考文献
AMGEN INC.; D'AMICO, Derin C.; HERBERICH, Bradley J.; JACKSON, Claire L.M.; PETTUS, Liping H.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan
Patent: WO2012/148775 A1, 2012 ;
Location in patent: Page/Page column 113; 114 ;
WO 2012/148775 A1
反应条件
KNO2; sulfuric acid anschliessend Behandeln mit Kupfer(I)-bromid;
参考文献
Graf
Journal fuer Praktische Chemie (Leipzig), 1932 , vol. <2> 133, p. 36,49
反应条件
copper(II) sulfate Diazotization;
参考文献
Raeth; Schiffmann
Justus Liebigs Annalen der Chemie, 1931 , vol. 487, p. 127,129
反应条件
1: aqueous CuSO4 / Diazotization 2: aqueous H2SO4 View Scheme
参考文献
Raeth; Schiffmann
Justus Liebigs Annalen der Chemie, 1931 , vol. 487, p. 127,129
反应条件
1: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 2: aqueous KMnO4 View Scheme
参考文献
Graf
Journal fuer Praktische Chemie (Leipzig), 1932 , vol. <2> 133, p. 36,49
反应条件
in toluene T=80°C; 15 h; Inert atmosphere;
参考文献
Vinogradova, Ekaterina V.; Fors, Brett P.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 27 p. 11132 - 11135
反应条件
1: With hydrogenchloride; sodium nitrite in water T=-5 - 0°C; 0.333333 h; 2: With HPF6 in water 3: With sodium hydroxide more than 3 stages;
参考文献
F2G LTD
Patent: WO2008/62182 A1, 2008 ;
Location in patent: Page/Page column 161 ;
反应条件
1: potassium nitrite; aqueous hydrochloric acid / Behandeln des Reaktionsprodukts mit Kupfer(I)-chlorid und wss. Salzsaeure 2: KMnO4; H2O View Scheme
参考文献
Graf
Journal fuer Praktische Chemie (Leipzig), 1932 , vol. <2> 133, p. 36,49
反应条件
Ki; sodium thiosulfate in ethylene glycol dimethyl ether; acetonitrile; pentane
参考文献
Abbott Laboratories
Patent: US5733912 A1, 1998 ;
