3-(4-硝基苯基)-1-丙胺合成路线 （共 12 条）
参考文献
Ingold; Wilson
Journal of the Chemical Society, 1927 , p. 811
反应条件
nitric acid
T=0 - 50°C;
参考文献
Zheng, Zhongli; Carter, Mary-Beth; Liao, YuSheng; Sun, Lihong; Kirkovsky, Leonid; Mrose, Susan; Hsu, Yen-Ming; Thomas, David; Shipps JR., Gerald W.; Jindal, Satish; Lenz, George R.; Nash, Huw M.
Patent: US2004/67982 A1, 2004 ;
Location in patent: Page/Page column 22-23 ;
反应条件
sodium borohydride; ammonia; acetic acid in 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform
参考文献
Mitsui Toatsu Chemicals, Incorporated
Patent: US5008267 A1, 1991 ;
反应条件
tris-(2-chloro-ethyl)-amine in chloroform
T=50°C; 4 h;
参考文献
Denny, William A.; Cain, Bruce F.; Atwell, Graham J.; Hansch, Corwin; Panthananickal, Augustine; Leo, A.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 276 - 300
反应条件
ammonia in 1,4-dioxane
T=90 - 100°C; 3 h;
参考文献
Katakami; Yokoyama; Miyamoto; Mori; Kawauchi; Nobori; San-nohe; Kaiho; Kamiya
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3325 - 3330
反应条件
1: pyridine / CHCl3 / 16 h / Ambient temperature
2: NH3 / dioxane / 3 h / 90 - 100 °C
View Scheme
参考文献
Katakami; Yokoyama; Miyamoto; Mori; Kawauchi; Nobori; San-nohe; Kaiho; Kamiya
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3325 - 3330
反应条件
1.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 20 °C
1.2: 91 percent / NaOH / Cl2Pd(PPh3)2 / tetrahydrofuran / 1.5 h / 20 °C
2.1: 86 percent / CF3COOH / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Nomura, Takashi; Iwaki, Tsutomu; Yasukata, Tatsuro; Nishi, Koichi; Narukawa, Yukitoshi; Uotani, Koichi; Hori, Toshihiko; Miwa, Hideaki
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6615 - 6628
反应条件
1: NH4NO3; (CF3CO)2O / CH2Cl2 / 10 - 20 °C
2: dimethylformamide / 2 h / Heating
3: N2H4*H2O / ethanol / 6 h / Heating
View Scheme
参考文献
Dannhardt, Gerd; Gruchalla, Markus V.; Kohl, Beate K.; Parsons
Archiv der Pharmazie, 2000 , vol. 333, # 8 p. 267 - 274
反应条件
nitric acid
T=-15 - 5°C;
参考文献
Ingold; Wilson
Journal of the Chemical Society, 1927 , p. 811
反应条件
1: 17.5 percent / diphenyl phosphorazidate, NEt3 / 5 h / Heating
2: trifluoroacetic acid / 0.25 h
View Scheme
参考文献
Hardy, George W.; Lowe, Lawrence A.; Mills, Gail; Sang, Pang Yih; Simpkin, Dean S. A.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1108 - 1118
