(2S)-2-({[(2-甲基-2-丙基)氧基]羰基}氨基)-2-苯丙酸合成路线 （共 7 条）
反应条件
trimethylammonium hydroxide in water; acetonitrile
T=20°C; 48 h;
参考文献
PHARMACIA ITALIA S.P.A.
Patent: WO2004/104007 A1, 2004 ;
Location in patent: Page 204 ;
WO 2004/104007 A1
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Dess-Martin periodane in water; tert-butyl alcohol
参考文献
Matsushita, Masayuki; Maeda, Hana; Kodama, Mitsuaki
Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3749 - 3752
反应条件
1: Et3N, 4-DMAP / tetrahydrofuran
2: Cs2CO3 / methanol
3: 1.) Dess-Martin reagent, NaClO2, 2-Me-2-butene, NaH2Po4 / 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Matsushita, Masayuki; Maeda, Hana; Kodama, Mitsuaki
Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3749 - 3752
反应条件
1: Et3N, 4-DMAP / tetrahydrofuran
2: Cs2CO3 / methanol
3: 1.) Dess-Martin reagent, NaClO2, 2-Me-2-butene, NaH2Po4 / 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Matsushita, Masayuki; Maeda, Hana; Kodama, Mitsuaki
Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3749 - 3752
反应条件
1: 87 percent / RuO4, NaIO4 / CCl4; acetonitrile; H2O
2: 62 percent / DPPA, Et3N / toluene / Heating
3: 98 percent / BF3*OEt2 / tetrahydrofuran
4: Et3N, 4-DMAP / tetrahydrofuran
5: Cs2CO3 / methanol
6: 1.) Dess-Martin reagent, NaClO2, 2-Me-2-butene, NaH2Po4 / 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Matsushita, Masayuki; Maeda, Hana; Kodama, Mitsuaki
Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3749 - 3752
反应条件
1: 62 percent / DPPA, Et3N / toluene / Heating
2: 98 percent / BF3*OEt2 / tetrahydrofuran
3: Et3N, 4-DMAP / tetrahydrofuran
4: Cs2CO3 / methanol
5: 1.) Dess-Martin reagent, NaClO2, 2-Me-2-butene, NaH2Po4 / 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Matsushita, Masayuki; Maeda, Hana; Kodama, Mitsuaki
Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3749 - 3752
反应条件
1: 98 percent / BF3*OEt2 / tetrahydrofuran
2: Et3N, 4-DMAP / tetrahydrofuran
3: Cs2CO3 / methanol
4: 1.) Dess-Martin reagent, NaClO2, 2-Me-2-butene, NaH2Po4 / 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Matsushita, Masayuki; Maeda, Hana; Kodama, Mitsuaki
Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3749 - 3752
