乙基氧代(2,3,5,6-四甲基苯基)乙酸酯合成路线 (共 3 条)
反应条件
1: chlorodurene With naphthalene; lithium in diethyl ether T=3 - 6°C; 3 h; 2: With copper (I) cyanide in tetrahydrofuran; diethyl ether T=3 - 6°C; 0.5 h; 3: oxalic acid monoethyl ester chloride in tetrahydrofuran; diethyl ether T=3 - 20°C; 1.33333 h; Cooling with ice;
参考文献
Screttas, Constantinos G.; Steele, Barry R.; Micha-Screttas, Maria; Heropoulos, Georgios A.
Organic Letters, 2012 , vol. 14, # 22 p. 5680 - 5683
反应条件
1: 1,4-dichloro-2,3,5,6-tetramethylbenzene With naphthalene; lithium in diethyl ether T=20°C; 19 h; 2: oxalic acid monoethyl ester chloride in diethyl ether T=20°C; Cooling with liquid nitrogen;
参考文献
Organic Letters, , vol. 14, # 22 p. 5680 - 5683
反应条件
1: 1,4-dichloro-2,3,5,6-tetramethylbenzene With lithium in diethyl ether T=20°C; 24 h; 2: oxalic acid monoethyl ester chloride in diethyl ether Overall yield = 1.51 g;
参考文献
Organic Letters, , vol. 14, # 22 p. 5680 - 5683