(3S-反式)-3-氨基-4-甲基-2-氧代-1-氮杂环丁烷磺酸合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; water 2 h; Ambient temperature;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 649 - 656
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Journal of Organic Chemistry, , vol. 47, # 1 p. 176 - 178
反应条件
formic acid 4.5 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 47, # 26 p. 5160 - 5167
反应条件
pyridine; phosgene in dichloromethane T=0°C; 41 h;
参考文献
Journal of Organic Chemistry, , vol. 47, # 1 p. 176 - 178
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 39, # 15 p. 2577 - 2589
反应条件
1: With triethylamine in ethanol; water T=-6 - -3°C; 3 h; 2: With hydrogenchloride in ethanol; water T=-3 - 0°C;
参考文献
Singh, Janak; Denzel, Theodor W.; Fox, Rita; Kissick, Thomas P.; Herter, Rolf; Wurdinger, Joseph; Schierling, Peter; Papaioannou, Chris G.; Moniot, Jerome L.; Mueller, Richard H.; Cimarusti, Christopher M.
Organic Process Research and Development, 2002 , vol. 6, # 6 p. 863 - 868
反应条件
1: With triethylamine in methanol; water T=0°C; pH=8 - 8.5; 2: With hydrogenchloride in methanol; water T=10°C; pH=1.3;
参考文献
Singh, Janak; Denzel, Theodor W.; Fox, Rita; Kissick, Thomas P.; Herter, Rolf; Wurdinger, Joseph; Schierling, Peter; Papaioannou, Chris G.; Moniot, Jerome L.; Mueller, Richard H.; Cimarusti, Christopher M.
Organic Process Research and Development, 2002 , vol. 6, # 6 p. 863 - 868
反应条件
1: With triethylamine in acetone T=10 - 15°C; 4 h; 2: With hydrogenchloride in water pH=~ 5.5;
参考文献
SICOR, INC.
Patent: WO2006/122253 A1, 2006 ;
Location in patent: Page/Page column 6 ;
