(R)-1-(3-氯苯基)-1,2-乙二醇合成路线 （共 16 条）
反应条件
1: With [Rh(Phebox-ip)]; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane; sodium t-butanolate in tetrahydrofuran T=60°C; 1 h; Inert atmosphere; 2: in tetrahydrofuran; water T=20°C; 1 h; Inert atmosphere; enantioselective reaction;
参考文献
Toribatake, Kenji; Nishiyama, Hisao
Angewandte Chemie - International Edition, 2013 , vol. 52, # 42 p. 11011 - 11015
Angewandte Chemie, 2013 , vol. 125, # 42 p. 11217 - 11221,5
反应条件
sodium chloride in tetrahydrofuran
参考文献
Nisshin Flour Milling Co., Ltd.
Patent: US6130243 A1, 2000 ;
反应条件
Geotrichum sp; water in N,N-dimethyl-formamide T=30°C; Reduction; 12 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 8, # 5 p. 1129 - 1137
反应条件
[(R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(III) acetate; water in tetrahydrofuran T=0 - 20°C; 48 h;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
(S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc; water in tetrahydrofuran T=0 - 20°C; 48 h;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
1: 2-(3-chlorophenyl)oxirane With water; (S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc in tetrahydrofuran T=0 - 20°C; 16 h; 2: N-Boc-2-nitrobenzenesulfonamide With oxygen in tetrahydrofuran T=20°C; 72 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 30 p. 3952 - 3954
反应条件
Solanum tuberosum Epoxide Hydrolase in water; dimethyl sulfoxide; glycerol T=20°C; 1.5 h;
参考文献
Monterde, Maria I.; Lombard, Murielle; Archelas, Alain; Cronin, Annette; Arand, Michael; Furstoss, Roland
Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2801 - 2805
反应条件
Tris-HCl buffer in hexane T=25°C; 48 h;
参考文献
Jia, Xin; Wang, Zunsheng; Li, Zhi
Tetrahedron Asymmetry, 2008 , vol. 19, # 4 p. 407 - 415
反应条件
carrot roots in water T=32°C; 28 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Liu, Xiang; Wang, Yi; Gao, Hai Yan; Xu, Jian He
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 635 - 638
反应条件
Aspergillus niger CGMCC 0496 in phosphate buffer; N,N-dimethyl-formamide T=25°C; pH=8.0; 0.4 h; Title compound not separated from byproducts.;
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 3 p. 408 - 414
