1-溴-4-(溴甲基)萘合成路线 （共 16 条）
反应条件
calcium carbonate in 1,4-dioxane; water T=110°C; 12 h; Inert atmosphere;
参考文献
Robbins, Jessica S.; Schmid, Kyle M.; Phillips, Scott T.
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3159 - 3169
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
Heating;
参考文献
Chen, Huixiong; Luzy, Jean-Philippe; Gresh, Nohad; Garbay, Christiane
European Journal of Organic Chemistry, 2006 , # 10 p. 2329 - 2335
反应条件
pyridine; phosphorus tribromide in benzene
T=55°C; 6 h;
参考文献
Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
反应条件
1.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C
1.2: 84 percent / tetrahydrofuran / 1 h / -78 - 20 °C
2.1: Mg; I2; EtI / tetrahydrofuran / 0.25 h / Heating
2.2: 75 percent / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
参考文献
Lee; Silverman
Tetrahedron, 2001 , vol. 57, # 25 p. 5339 - 5352
反应条件
1.1: Mg; I2; EtI / tetrahydrofuran / 0.25 h / Heating
1.2: 75 percent / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
参考文献
Lee; Silverman
Tetrahedron, 2001 , vol. 57, # 25 p. 5339 - 5352
反应条件
1: 87 percent / AlCl3 / CH2Cl2 / 1.) 0 deg C; 2.) ambient temp. 4 h; 3.) reflux, 2.5 h
2: 94 percent / NaOCl / H2O / 4.5 h / Heating
3: 25 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h; 2.) room temperature, 14 h
4: 84.5 percent / PBr3, pyridine / benzene / 6 h / 55 °C
View Scheme
参考文献
Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
反应条件
1: 25 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h; 2.) room temperature, 14 h
2: 84.5 percent / PBr3, pyridine / benzene / 6 h / 55 °C
View Scheme
参考文献
Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
反应条件
1: 94 percent / NaOCl / H2O / 4.5 h / Heating
2: 25 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h; 2.) room temperature, 14 h
3: 84.5 percent / PBr3, pyridine / benzene / 6 h / 55 °C
View Scheme
参考文献
Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
反应条件
1: bromine
2: durch Bromierung im Licht einer Bogenlampe
View Scheme
参考文献
Mayer,F.; Sieglitz
Chemische Berichte, 1922 , vol. 55, p. 1854
反应条件
sulfuric acid; acetic acid; sodium bromide
参考文献
Mamalis,P. et al.
Journal of the Chemical Society, 1962 , p. 3915 - 3926
