5-(溴甲基)-4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶合成路线 （共 15 条）
反应条件
water in tetrahydrofuran 6 h; Reflux;
参考文献
Sterk, Damjan; Casar, Zdenko; Jukic, Marko; Kosmrlj, Janez
Tetrahedron, 2012 , vol. 68, # 9 p. 2155 - 2160
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide T=20°C; Kornblum oxidation; 71 h; Inert atmosphere;
参考文献
Sterk, Damjan; Casar, Zdenko; Jukic, Marko; Kosmrlj, Janez
Tetrahedron, 2012 , vol. 68, # 9 p. 2155 - 2160
反应条件
1: With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide Kornblum Oxydation; 25 h; 2: With acetic anhydride; dimethyl sulfoxide T=70°C;
参考文献
WO2012/13325 A1, ;
Page/Page column 63 ;
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide T=20°C; Kornblum oxidation; 71 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 68, # 9 p. 2155 - 2160
反应条件
in toluene
T=20°C; 18 h; Inert atmosphereReflux;
参考文献
Kaneka Corporation
Patent: EP2351762 A1, 2011 ;
Location in patent: Page/Page column 10 ;
