9H-吡啶并[3,4-b]吲哚-1-甲腈合成路线 （共 16 条）
反应条件
trichlorophosphate in toluene
Heating;
参考文献
Rinehart,K.B.; Kobayashi,J.; Harbour,G.C.
Journal of the American Chemical Society, 1987 , vol. 109, p. 3378
反应条件
N,N-diethyl carbamoyl chloride in 1,4-dioxane
T=80°C; 16 h;
参考文献
Kast, Oliver; Bracher, Franz
Synthetic Communications, 2003 , vol. 33, # 22 p. 3843 - 3850
反应条件
1: 81 percent / HCl / Ambient temperature
2: 91 percent / conc aq. NH4OH / Ambient temperature
3: 75 percent / 5percent Pd/C / xylene / 4 h / Heating
4: 77 percent / POCl3 / toluene / Heating
View Scheme
参考文献
Rinehart,K.B.; Kobayashi,J.; Harbour,G.C.
Journal of the American Chemical Society, 1987 , vol. 109, p. 3378
反应条件
sodium hydroxide in dichloromethane; ethyl acetate
参考文献
Mochida Pharmaceutical Co., Ltd.
Patent: US6476021 B1, 2002 ;
反应条件
lithium chloride; tetrakis(triphenylphosphine) palladium(0); 18-crown-6 ether in toluene
7 h; Heating;
参考文献
Bracher; Hildebrand; Ernst
Archiv der Pharmazie, 1994 , vol. 327, # 2 p. 121 - 122
反应条件
N,N-diethyl carbamoyl chloride in 1,4-dioxane
T=80°C; 16 h;
参考文献
Kast, Oliver; Bracher, Franz
Synthetic Communications, 2003 , vol. 33, # 22 p. 3843 - 3850
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in benzene
0.75 h; Heating;
参考文献
Veeraraghavan, Seshardi; Popp, Frank D.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 909 - 915
反应条件
1: 55 percent / pyridine / 7 h / Ambient temperature
2: 71 percent / LiCl / Pd(PPh3)4, 18-crown-6 / toluene / 7 h / Heating
View Scheme
参考文献
Bracher; Hildebrand; Ernst
Archiv der Pharmazie, 1994 , vol. 327, # 2 p. 121 - 122
反应条件
1: 49 percent / AlCl3 / CH2Cl2 / 63 h
2: 48 percent / DDQ / benzene / 0.75 h / Heating
View Scheme
参考文献
Veeraraghavan, Seshardi; Popp, Frank D.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 909 - 915
反应条件
1: 85 percent / 3-chloroperoxybenzoic acid / CHCl3; ethanol / 2 h / Heating
2: 90 percent / Et2N-COCl / dioxane / 16 h / 80 °C
View Scheme
参考文献
Kast, Oliver; Bracher, Franz
Synthetic Communications, 2003 , vol. 33, # 22 p. 3843 - 3850
