N-苯甲酰-L-苏氨酸甲酯合成路线 （共 10 条）
反应条件
triethylamine in methanol T=0°C; 2 h;
参考文献
Liang, Xiaofei; Lee, Chul-Jin; Chen, Xin; Chung, Hak Suk; Zeng, Daina; Raetz, Christian R.H.; Li, Yaoxian; Zhou, Pei; Toone, Eric J.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 2 p. 852 - 860
反应条件
1: L-threonine methyl ester hydrochloride With triethylamine in methanol T=20°C; 0.25 h; 2: benzoyl chloride in methanol T=0°C; 2.16667 h;
参考文献
DUKE UNIVERSITY; ZHOU, Pei; TOONE, Eric, J.
Patent: WO2012/31298 A2, 2012 ;
Location in patent: Page/Page column 99-100 ;
WO 2012/031298 A2
反应条件
triethylamine in dichloromethane T=0°C; 12 h;
参考文献
Ait-Haddou, Hassan; Hoarau, Olivier; Cramailere, Dimitri; Pezet, Frederic; Daran, Jean-Claude; Balavoine, Gilbert G. A.
Chemistry - A European Journal, 2004 , vol. 10, # 3 p. 699 - 707
参考文献
Ranganathan; Vaish; Shah
Journal of the American Chemical Society, 1994 , vol. 116, # 15 p. 6545 - 6557
反应条件
hydrogen; RuCl2(DMF)n in methanol; dichloromethane T=60°C; P=38002.6 Torr; 24 h; Title compound not separated from byproducts.;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 11 p. 1278 - 1283
反应条件
1: aqueous HCl / anschliessend Behandeln mit wss. NaOH 2: diethyl ether View Scheme
参考文献
Journal of the Chemical Society, , p. 62,66, 67
反应条件
1: 89 percent / Dess-Martin periodinane / CH2Cl2 / 0.17 h / 22 °C 2: 74 percent / Ph3P, I2, Et3N / CH2Cl2 / 0.33 h / 22 °C View Scheme
参考文献
Wipf, Peter; Cunningham, April; Rice, Robert L.; Lazo, John S.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 1 p. 165 - 177
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; acetonitrile 1.5 h; Ambient temperaturepH 3;
参考文献
Ranganathan; Vaish; Shah
Journal of the American Chemical Society, 1994 , vol. 116, # 15 p. 6545 - 6557
反应条件
1: 89 percent / Dess-Martin periodinane / CH2Cl2 / 0.17 h / 22 °C 2: 74 percent / Ph3P, I2, Et3N / CH2Cl2 / 0.33 h / 22 °C 3: 95 percent / aq. NaOH / methanol / 2 h / 22 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 165 - 177
反应条件
Dess-Martin periodane in dichloromethane
T=22°C; 0.166667 h;
参考文献
Wipf, Peter; Cunningham, April; Rice, Robert L.; Lazo, John S.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 1 p. 165 - 177
