甲基(5-氰基-1-甲基-1H-吲哚-3-基)乙酸酯合成路线 （共 4 条）
反应条件
1: methyl (5-cyano-1H-indol-3-yl)acetate With sodium hydride in N,N-dimethyl-formamide
T=0°C;
2: methyl iodide in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Batt, Douglas G.; Qiao, Jennifer X.; Modi, Dilip P.; Houghton, Gregory C.; Pierson, Deborah A.; Rossi, Karen A.; Luettgen, Joseph M.; Knabb, Robert M.; Jadhav; Wexler, Ruth R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5269 - 5273
反应条件
triethylsilane; trifluoroacetic acid
T=20°C; 20 h;
参考文献
Han; Dominguez; Stouten; Park; Duffy; Galemmo Jr.; Rossi; Alexander; Smallwood; Wong; Wright; Luettgen; Knabb; Wexler
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4398 - 4415
反应条件
1.1: diethyl ether / 3.5 h / 20 °C
2.1: 18 h / 20 °C
3.1: NaH / dimethylformamide / 0.33 h / 20 °C
3.2: dimethylformamide / 2 h / 20 °C
4.1: Et3SiH; TFA / 20 h / 20 °C
View Scheme
参考文献
Han; Dominguez; Stouten; Park; Duffy; Galemmo Jr.; Rossi; Alexander; Smallwood; Wong; Wright; Luettgen; Knabb; Wexler
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4398 - 4415
反应条件
1.1: NaH / dimethylformamide / 0.33 h / 20 °C
1.2: dimethylformamide / 2 h / 20 °C
2.1: Et3SiH; TFA / 20 h / 20 °C
View Scheme
参考文献
Han; Dominguez; Stouten; Park; Duffy; Galemmo Jr.; Rossi; Alexander; Smallwood; Wong; Wright; Luettgen; Knabb; Wexler
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4398 - 4415
