1-(2,6-二氯吡啶-4-基)哌嗪合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 0.5 h;
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
反应条件
1.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -5 °C
1.2: 89 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C
2.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -20 °C
2.2: 78 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C
3.1: 57 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
反应条件
1.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -20 °C
1.2: 78 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C
2.1: 57 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
反应条件
1.1: 84 percent / triethylamine / dimethylformamide / 6 h / 100 °C
2.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -5 °C
2.2: 89 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C
3.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -20 °C
3.2: 78 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C
4.1: 57 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
