1,4-二氢-6-甲基-4-氧代-3-喹啉羧酸乙酯合成路线 （共 9 条）
反应条件
1: With hydrogenchloride; sodium hydroxide in methanol T=2.5°C; Reflux; 2: T=250 - 260°C;
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
thionyl chloride 17 h; Heating;
参考文献
Reis, Raisa Da R.; Azevedo, Elisa C.; De Souza, Maria Cecilia B.V.; Ferreira, Vitor Francisco; Montenegro, Raquel C.; Araujo, Ana Jersia; Pessoa, Claudia; Costa-Lotufo, Leticia V.; De Moraes, Manoel O.; Filho, Jose D.B.M.; De Souza, Alessandra M.T.; De Carvalho, Natasha C.; Castro, Helena C.; Rodrigues, Carlos R.; Vasconcelos, Thatyana R.A.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1448 - 1452
反应条件
1.1: sodium hydroxide; hydrogenchloride / methanol / 2.5 °C / |Reflux 1.2: Dowtherm-A / 250 - 260 °C 2.1: trichlorophosphate; ammonium hydroxide / |Reflux View Scheme
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
in diphenylether
T=220 - 250°C;
参考文献
El-Essawy, Farag A.; El-Sayed, Wael A.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # SUPPL.1 p. E1-E8
反应条件
1: 87 percent / 3 h / Heating
2: 75 percent / various solvent(s) / 1.15 h / Heating
View Scheme
参考文献
Da Matta; Bernardino; Romeiro; De Oliveira; De Souza; Ferreira
Nucleosides and Nucleotides, 1996 , vol. 15, # 4 p. 889 - 898
反应条件
Gould-Jacob reaction; 0.0708333 h; Irradiation;
参考文献
Dave, Chaitanya G.; Joshipura, Hardik M.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 3 p. 650 - 652
反应条件
1: ethanol / Reflux
2: diphenylether / Reflux
View Scheme
参考文献
Reis, Raisa Da R.; Azevedo, Elisa C.; De Souza, Maria Cecilia B.V.; Ferreira, Vitor Francisco; Montenegro, Raquel C.; Araujo, Ana Jersia; Pessoa, Claudia; Costa-Lotufo, Leticia V.; De Moraes, Manoel O.; Filho, Jose D.B.M.; De Souza, Alessandra M.T.; De Carvalho, Natasha C.; Castro, Helena C.; Rodrigues, Carlos R.; Vasconcelos, Thatyana R.A.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1448 - 1452
反应条件
1.1: thionyl chloride / 17 h / Heating
2.1: toluene / 3 h
2.2: 78 percent / acetic acid / 2 h / Heating
View Scheme
参考文献
De Oliveira, Mara R. P.; Alves, Thatyana R.; Pinto, Angelo C.; Pereira, Helena De S.; Leao-Ferreira, Luiz R.; Moussatche, Nissin; Frugulhetti, Izabel Christina De P. P.; Ferreira, Vitor F.; De Souza, Maria Cecilia B. V.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 5 p. 735 - 748
反应条件
1: With hydrogenchloride; sodium hydroxide in methanol
T=2.5°C; Reflux;
2: T=250 - 260°C;
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
