2-氨基-3-氯-5-三氟甲基吡啶合成路线 （共 14 条）
反应条件
ammonia in tetrahydrofuran T=35°C; P=1950.2 Torr; 28 h; AutoclaveInert atmosphere; Product distribution / selectivity;
参考文献
FINCHIMICA S.p.A.; PASTORIO, Andrea; MORA, Claudia
Patent: WO2011/92618 A1, 2011 ;
Location in patent: Page/Page column 9-11 ;
反应条件
ammonium hydroxide T=100 - 125°C; P=1520 Torr; 29 h;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
反应条件
hydrogenchloride; acetic acid in toluene
反应条件
hydrogenchloride; chlorine T=50 - 60°C;
参考文献
Heterocycles, , vol. 22, # 1 p. 117 - 124
反应条件
1: 39 percent / aq. ammonia / 8 h / 180 °C 2: chlorine, conc.HCl / 50 - 60 °C View Scheme
参考文献
Heterocycles, , vol. 22, # 1 p. 117 - 124
反应条件
1: 54.5 percent / antimony trifluoride / 0.17 h / Heating 2: 39 percent / aq. ammonia / 8 h / 180 °C 3: chlorine, conc.HCl / 50 - 60 °C View Scheme
参考文献
Heterocycles, , vol. 22, # 1 p. 117 - 124
反应条件
1: 80.4 percent / antimony trifluoride / 0.17 h / Heating; Irradiation 2: 82.9 percent / aq. ammonia / 29 h / 100 - 125 °C / 1520 Torr View Scheme
参考文献
Heterocycles, , vol. 22, # 1 p. 117 - 124
反应条件
in ethanol T=20 - 80°C; 12 h;
参考文献
EXELIXIS, INC.; CANNE BANNEN, Lynne; CHAN, Diva Sze-ming; GU, Xiao-hui; MAC, Morrison, B.; NG, Stephanie; WANG, Tie-lin; WANG, Yong; XU, Wei
Patent: WO2010/65760 A1, 2010 ;
Location in patent: Page/Page column 102 ;
WO 2010/065760 A1
反应条件
potassium hydroxide in methyl isobutyl ketone (MIBK) T=25 - 30°C; Product distribution / selectivity;
参考文献
MAKHTESHIM CHEMICAL WORKS LTD.
Patent: WO2007/60662 A2, 2007 ;
Location in patent: Page/Page column 25-27 ;
