2,4,16a-三溴雌酮合成路线 （共 10 条）
反应条件
1: 89 percent / sodium, D2O, pyridine / 2 h / Ambient temperature 2: 68 percent / p-TsOH*H2O / toluene / 7 h / Heating 3: 81 percent / NaBD4, PdCl2 / CH3OD / 6 h / 0 °C View Scheme
参考文献
Numazawa; Nagaoka; Ogata
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 618 - 622
反应条件
1: 90 percent / pyridine, sodium hydroxide / H2O / 3 h / Ambient temperature 2: 96 percent / NaBH4, PdCl2 / methanol / 2 h / 0 °C View Scheme
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
1: 97 percent / NaOH, 75percent aq. pyridine / 3 h / Ambient temperature 2: 85 percent / Ag2CO3 / benzene / 72 h / Ambient temperature 3: NaBH4 / PdCl2 / methanol / 0.5 h / 0 °C 4: hydrolysis View Scheme
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
copper(ll) bromide in methanol
48 h; Heating;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Chemical Communications, 1981 , # 8 p. 383 - 384
反应条件
copper(ll) bromide in methanol
6.5 h; Heatingfurther time, further reagent;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
bromine in chloroform; acetic acid
1.) room temperature, 2 h, 2.) 50 deg C, 1 h;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
copper(ll) bromide in methanol
32 h; Heating;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
copper(ll) bromide in methanol
24 h; Heating;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
bromine in chloroform; acetic acid
2 h; Ambient temperatureother reagent, other time; Product distribution;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
pyridine; sodium hydroxide
3 h; Ambient temperature;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Chemical Communications, 1981 , # 8 p. 383 - 384
