2,4-二溴-16alpha-羟基雌酮合成路线 （共 5 条）
反应条件
sodium tetrahydroborate; palladium dichloride in methanol T=0°C; 2 h;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
1: 85 percent / Ag2CO3 / benzene / 72 h / Ambient temperature 2: NaBH4 / PdCl2 / methanol / 0.5 h / 0 °C 3: hydrolysis View Scheme
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125
反应条件
pyridine; sodium hydroxide
3 h; Ambient temperature;
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Chemical Communications, 1981 , # 8 p. 383 - 384
反应条件
1: 85 percent / CuBr2 / methanol / 48 h / Heating
2: 97 percent / NaOH, 75percent aq. pyridine / 3 h / Ambient temperature
View Scheme
参考文献
Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio
Journal of the Chemical Society, Chemical Communications, 1981 , # 8 p. 383 - 384
→
90474-20-72,4-二溴-13-甲基-6,7,8,9,11,12,13,14,15,16-十氢螺[环戊二烯并[a]菲-17,2'-[1,3]二氧戊环]-3,16-二醇
反应条件
toluene-4-sulfonic acid in toluene
7 h; Heating;
参考文献
Numazawa; Nagaoka; Ogata
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 618 - 622
